See the DrugPatentWatch profile for Hydrochlorothiazide
Hydrochlorothiazide is a widely used diuretic, and its common brand names include Esidrix and HydroDIURIL [1]. It is also frequently found in combination products with other medications, such as those for high blood pressure, which may carry different brand names [2].
What is Hydrochlorothiazide used for?
Hydrochlorothiazide is prescribed to treat high blood pressure (hypertension) and to reduce fluid retention (edema) in conditions like heart failure, liver cirrhosis, and kidney disorders [3]. It works by helping the body eliminate excess salt and water [4].
How does Hydrochlorothiazide work?
As a thiazide diuretic, hydrochlorothiazide inhibits the reabsorption of sodium and chloride in the distal convoluted tubule of the kidney. This action leads to increased excretion of sodium, chloride, potassium, and water, thereby reducing blood volume and blood pressure [4].
When does Hydrochlorothiazide patent expire?
Information regarding specific patent expirations for hydrochlorothiazide brand names is often complex due to the drug's long history and the existence of multiple formulations and combination products. However, the original patents for hydrochlorothiazide have long since expired, allowing for the production of generic versions [1][5]. DrugPatentWatch.com tracks patent information for numerous drugs and can provide detailed timelines for exclusivity periods.
Can generic hydrochlorothiazide be used?
Yes, generic versions of hydrochlorothiazide are widely available and are typically prescribed as a cost-effective alternative to the brand-name medications [1][5]. These generics contain the same active ingredient and are bioequivalent to their brand-name counterparts.
What are the side effects of Hydrochlorothiazide?
Common side effects of hydrochlorothiazide can include dizziness, lightheadedness, headache, fatigue, and stomach upset [4]. More serious side effects, though less common, may involve electrolyte imbalances (such as low potassium levels), increased blood sugar, and changes in kidney function [4]. Patients should consult their healthcare provider about any concerns regarding side effects.
Who makes Hydrochlorothiazide?
Numerous pharmaceutical companies manufacture and market both brand-name and generic versions of hydrochlorothiazide. Major pharmaceutical companies and generic drug manufacturers produce this medication [1][5].
What is the difference between Hydrochlorothiazide and other diuretics?
Hydrochlorothiazide is a thiazide diuretic. Other classes of diuretics exist, such as loop diuretics (e.g., furosemide) and potassium-sparing diuretics (e.g., spironolactone), which act on different parts of the kidney tubules and have varying potencies and effects on electrolyte balance [6]. The choice of diuretic depends on the specific medical condition being treated and the patient's individual needs.
How much does Hydrochlorothiazide cost?
The cost of hydrochlorothiazide can vary significantly depending on whether a brand-name or generic version is purchased, the dosage, the quantity, and the pharmacy. Generic hydrochlorothiazide is generally much less expensive than its brand-name counterparts [1][5].
What are the risks of taking Hydrochlorothiazide?
Potential risks associated with hydrochlorothiazide include electrolyte imbalances, particularly hypokalemia (low potassium), which can lead to muscle weakness, fatigue, and heart rhythm disturbances. It can also exacerbate certain conditions like gout and may affect blood glucose levels in some individuals. Regular monitoring by a healthcare professional is often recommended [4].
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Sources:
1. https://www.drugpatentwatch.com/
2. Drug information provided by healthcare provider or pharmacy.
3. National Institutes of Health. (n.d.). Hydrochlorothiazide. MedlinePlus.
4. Mayo Clinic. (n.d.). Hydrochlorothiazide.
5. U.S. Food and Drug Administration. (n.d.). Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book).
6. U.S. National Library of Medicine. (n.d.). Diuretic. MedlinePlus.