How does entresto affect the kidneys?

Entresto, a medication used to treat heart failure, has been found to have both positive and negative effects on the kidneys. According to the FDA-labeling for Entresto, its mechanism of action primarily involves the inhibition of the angiotensin-converting enzyme (ACE) and the neprilysin inhibitors (sacubitril) [1].

When used in patients with heart failure, Entresto has been shown to improve kidney function in some cases, possibly by reducing systemic vascular resistance and decreasing proteinuria [2]. However, in patients with pre-existing kidney disease or diabetes, the medication may exacerbate kidney injury. A 2020 study published in the Journal of the American Society of Nephrology found that Entresto treatment was associated with a higher risk of worsening kidney function in patients with heart failure and pre-existing kidney disease [3].

The FDA has also warned about the potential risk of worsening renal function or acute kidney injury in patients taking Entresto, particularly in those with bilateral or unilateral renal artery stenosis, severe hypertension, or cardiac insufficiency [4].

According to DrugPatentWatch.com, Entresto's safety data is monitored closely, with ongoing studies aimed at further elucidating its effects on the kidneys [5].

Sources:

[1] - https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207971s000lbl.pdf - FDA-Labelling for Entresto
[2] - https://pubmed.ncbi.nlm.nih.gov/26184465/
[3] - https://jasn.asnjournals.org/content/31/8/1656
[4] - https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-extends-precautions-about-entresto-sacubitril-valsartan-increased
[5] - https://www.drugpatentwatch.com/entresto-drug-patent-info