Rare but Serious Side Effects of Keytruda
Keytruda (pembrolizumab) is a cancer immunotherapy medication that has been associated with several rare but severe side effects [1]. These side effects can be life-threatening and require immediate medical attention.
Immune-Related Adverse Reactions
Keytruda works by stimulating the immune system to fight cancer cells. However, this can also lead to an overactive immune response, causing a range of side effects. Some of the rare but serious immune-related adverse reactions associated with Keytruda include:
* Colitis: inflammation of the colon, which can be severe and life-threatening [1].
* Pneumonitis: inflammation of the lungs, which can lead to shortness of breath, chest pain, and respiratory failure [1].
* Hepatitis: inflammation of the liver, which can cause jaundice, fatigue, and nausea [1].
Neurological Side Effects
Keytruda has also been linked to rare but serious neurological side effects, including:
* Encephalitis: inflammation of the brain, which can cause confusion, seizures, and coma [2].
* Guillain-Barré Syndrome: a rare autoimmune disorder that can cause muscle weakness, paralysis, and respiratory failure [2].
Endocrine Dysfunction
Keytruda has been associated with endocrine dysfunction, including:
* Hypophysitis: inflammation of the pituitary gland, which can cause fatigue, weight loss, and sexual dysfunction [1].
* Adrenal insufficiency: a condition characterized by adrenal gland failure, which can lead to fatigue, weight loss, and low blood pressure [1].
Other Rare Side Effects
In addition to the side effects listed above, Keytruda has been linked to other rare but serious conditions, including:
* Myasthenia Gravis: a autoimmune disorder that can cause muscle weakness and respiratory failure [2].
* Thyroiditis: inflammation of the thyroid gland, which can cause hyperthyroidism or hypothyroidism [1].
It is essential to discuss the potential side effects of Keytruda with a healthcare provider before starting treatment.
References:
[1] https://www.drugpatentwatch.com/patent/US/US-7682746-B2/
[2] Keytruda prescribing information. Merck & Co., Inc., 2022.
Please note that this is a list of potential side effects and is not intended to be comprehensive. Patients should consult their healthcare provider for specific information about the risks and benefits associated with Keytruda treatment.