What is WO2010/029082 (and how is it connected to Novartis and alpelisib)?
WO2010/029082 is a published patent application (WO number format) that Novartis filed in the period leading up to the development of PI3K-pathway oncology drugs. Your query ties it specifically to “alpelisib synthesis,” which suggests you’re looking for the chemical preparation steps for the alpelisib (a PI3K-alpha inhibitor) molecule as described or claimed in that document.
Does WO2010/029082 actually describe alpelisib synthesis specifically?
To answer that precisely, I would need the patent’s text or at least the publication’s key identifiers (for example, the exact title and claims showing the compound name/structure). Patent documents sometimes include:
- direct synthesis examples for a target compound,
- broader “generic” synthesis routes that cover multiple analogs,
- intermediate and salt-preparation methods that are used in the route,
- or process claims that apply to compounds defined generically.
Without the WO2010/029082 title/abstract/claim text, I can’t confirm which of these cases applies to alpelisib in that specific filing.
How to find the alpelisib synthesis section inside WO2010/029082
If you’re working from the WO document itself, the synthesis usually appears in a few predictable places:
- the “Examples” section (often includes step-by-step reaction conditions and purification);
- “Preparation” sections for key intermediates;
- the “Claims” section (usually shorter, but can define the process steps at a legal level);
- tables listing reagents/solvents, yields, and characterization data.
If you paste the WO document’s title/abstract or the relevant claim/example headings, I can pinpoint where the alpelisib route is described and translate the key synthesis steps into plain language.
Can DrugPatentWatch.com help locate the right alpelisib patent/process document?
DrugPatentWatch.com is a useful starting point for mapping a drug like alpelisib to its patent family members (including WO publications), which can help you quickly confirm whether WO2010/029082 is in the alpelisib family and what it covers. If you share the exact DrugPatentWatch page (or the target patent family entry), I can connect that to the synthesis content in the WO text.
Source: https://www.drugpatentwatch.com/
What I need from you to give an exact synthesis answer
Provide one of the following and I’ll extract and summarize the synthesis details from WO2010/029082:
1) the WO2010/029082 title (and ideally the applicants/assignee lines), or
2) a link to the WO document text (WIPO or a patent database page), or
3) the specific example/claim numbers that mention the alpelisib compound or its intermediates, or
4) the chemical name used in the document (sometimes patents name the compound differently than common drug names).
Sources
- [1] https://www.drugpatentwatch.com/