Advil is a brand name for ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain, fever, and inflammation. According to Drug Patent Watch [1], ibuprofen works by reducing the production of prostaglandins, which are chemicals that cause pain, inflammation, and fever.

Insomnia is a sleep disorder that is characterized by difficulty falling asleep, staying asleep, or both. SingleCare [2] suggests that certain medications, including NSAIDs like Advil, can cause insomnia as a side effect. However, the exact mechanism by which ibuprofen causes insomnia is not clear.

A study published in the Journal of Clinical Psychopharmacology [3] investigated the effects of ibuprofen on sleep in healthy volunteers. The study found that taking ibuprofen at bedtime did not significantly affect sleep quality or duration compared to a placebo. However, the study only included a small number of participants and did not examine the effects of long-term ibuprofen use on sleep.

In conclusion, while some sources suggest that ibuprofen can cause insomnia as a side effect, the evidence is not conclusive. A small study found that taking ibuprofen at bedtime did not significantly affect sleep quality or duration, but more research is needed to fully understand the relationship between ibuprofen and insomnia. If you are experiencing sleep problems, it is important to talk to your doctor to determine the underlying cause and appropriate treatment.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] https://www.singlecare.com/blog/medications-that-cause-insomnia/
[3] https://pubmed.ncbi.nlm.nih.gov/8047572/