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See the DrugPatentWatch profile for rifampin
How does rifampin affect tigecycline blood levels? Rifampin speeds up the metabolism and elimination of tigecycline, lowering its blood concentration. Because of this, patients taking both drugs may reach sub-therapeutic levels of tigecycline. Does the manufacturer recommend a dose increase? No. The prescribing information does not suggest raising the tigecycline dose when co-administered with rifampin. What clinical guidance exists for this interaction? Current guidelines advise monitoring for reduced efficacy and considering an alternative antibiotic rather than adjusting the tigecycline dose.
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