Tigecycline is an antibiotic used to treat various bacterial infections, and its long-term use may pose potential risks. According to the information provided, the following potential risks have been associated with long-term tigecycline use [${2}, ${3}]:

1. Development of bacterial resistance: Prolonged use of tigecycline can contribute to the development of bacterial resistance, making it less effective in treating infections [${3}].

2. Gastrointestinal side effects: Long-term tigecycline use may increase the risk of gastrointestinal side effects, such as nausea, vomiting, and diarrhea [${2}].

3. Hepatotoxicity: There is a potential risk of hepatotoxicity associated with long-term tigecycline use, which may affect liver function [${2}].

4. Pancreatitis: Long-term tigecycline use has been linked to an increased risk of pancreatitis [${2}].

It is essential to note that the risks mentioned above are potential risks, and individual experiences may vary. Healthcare professionals should carefully weigh the benefits and risks of tigecycline when considering long-term use [${1}, ${2}, ${3}].

Sources:

[1] <https://www.drugpatentwatch.com/p/tradename/TIGECYCLINE>
[2] <https://www.pfizermedicalinformation.com/tygacil/warnings>
[3] <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210309/>