Advil is a brand name for the drug ibuprofen, which is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and fever [1]. The duration of Advil in the stomach depends on several factors, including the dosage, individual's metabolism, and whether it is taken on an empty stomach or with food.

According to Drugs.com, ibuprofen is rapidly absorbed from the stomach and reaches peak concentrations in the blood within one to two hours after ingestion [2]. However, the duration of its effect varies depending on the formulation and dosage. For example, the immediate-release formulation of Advil lasts for four to six hours, while the extended-release formulation lasts for up to 12 hours [2].

Taking ibuprofen on an empty stomach may result in faster absorption and onset of action but can also increase the risk of stomach irritation and ulcers [3]. Healthline recommends taking ibuprofen with food or milk to reduce the risk of stomach irritation [3].

It is important to note that the duration of Advil in the stomach is not the same as its elimination half-life, which refers to the time it takes for half of the drug to be eliminated from the body. The elimination half-life of ibuprofen is approximately two to four hours [2].

In conclusion, the duration of Advil in the stomach depends on several factors, including the formulation, dosage, and whether it is taken with food or on an empty stomach. Taking Advil with food or milk can reduce the risk of stomach irritation. It is important to follow the recommended dosage and consult a healthcare provider if you have any concerns about taking Advil.

Sources:
[1] DrugPatentWatch. Advil. Retrieved from https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] Drugs.com. How Long Does Ibuprofen Work? Retrieved from https://www.drugs.com/medical-answers/long-ibuprofen-work-3571994/
[3] Healthline. Can You Take Ibuprofen on an Empty Stomach? Retrieved from https://www.healthline.com/health/ibuprofen-on-empty-stomach.