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Does lipitor absorption increase with grapefruit oil?



Lipitor is a medication used to treat high cholesterol levels. It is a type of statin drug that works by reducing the amount of cholesterol produced by the liver. The active ingredient in Lipitor is atorvastatin [1].

Grapefruit juice is known to interact with some medications, including statins like Lipitor. Grapefruit juice contains compounds that inhibit the activity of an enzyme in the liver that is responsible for breaking down certain drugs. As a result, the levels of these drugs in the bloodstream can increase, leading to potentially dangerous side effects [2].

However, it is unclear whether grapefruit oil has the same effect as grapefruit juice on drug metabolism. A study published in the Journal of Clinical Lipidology found that consuming grapefruit essential oil did not affect the pharmacokinetics of atorvastatin [3].

In conclusion, while grapefruit juice is known to interact with Lipitor and increase its absorption, there is no evidence to suggest that grapefruit oil has the same effect. It is important to consult with a healthcare provider before making any changes to medication regimens or dietary habits.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.health.harvard.edu/heart-health/grapefruit-juice-and-statins
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589309/



Follow-up:   How much grapefruit oil is needed for absorption? Are there any risks with combining Lipitor and grapefruit oil? Does Lipitor effectiveness increase with grapefruit oil?





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