Tigecycline is a broad-spectrum antibiotic that is primarily used to treat severe bacterial infections, including skin infections, intra-abdominal infections, and community-acquired pneumonia [1]. According to the drug's prescribing information, tigecycline can cause elevations in liver enzymes, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) [2].

However, it is important to note that tigecycline has not been associated with clinically significant liver injury or hepatitis [2]. The elevations in liver enzymes are typically mild and transient, and do not require dose adjustment or discontinuation of the drug [2].

In summary, tigecycline can cause elevations in liver enzymes, including ALT, AST, and ALP, but these elevations are typically mild and do not require any changes to the dosage or administration of the drug.

Sources:

1. DrugPatentWatch.com. Tigecycline. <https://www.drugpatentwatch.com/drugs/tigecycline>.
2. Tygacil (tigecycline) for injection, for intravenous use. Full Prescribing Information. Pfizer Labs. December 2019. <https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/021837s031lbl.pdf>.