Cresemba 186 mg capsule?

What is Cresemba 186 mg capsule used for?

Cresemba 186 mg capsule, also known as isavuconazonium sulfate, is an antifungal medication used to treat invasive aspergillosis and mucormycosis in adults. It works by interfering with the growth of the fungal cells, ultimately leading to the death of the fungus. [1]

How does Cresemba work?

Cresemba contains isavuconazole, which is a triazole antifungal agent. It inhibits the synthesis of ergosterol, a crucial component of fungal cell membranes, ultimately leading to the death of the fungal cells. [2]

What are the benefits and risks of taking Cresemba?

The benefits of taking Cresemba include effective treatment of invasive aspergillosis and mucormycosis, with a favorable safety profile compared to other antifungal medications. However, potential risks include liver toxicity, gastrointestinal adverse events, and allergic reactions. [3]

How is Cresemba administered?

Cresemba is available in capsule form, and the recommended dosage is 200 mg every 8 hours for invasive aspergillosis and 372 mg every 8 hours for mucormycosis. The capsules should be taken orally with food. [4]

When does exclusivity expire?

The U.S. Food and Drug Administration (FDA) granted orphan drug designation to isavuconazonium sulfate for the treatment of invasive mucormycosis, and the drug is protected by a special exclusivity agreement until April 2029. [5]

What is the typical cost of Cresemba?

The cost of Cresemba can range from $50 to $100 per capsule, depending on the insurance coverage and pharmacy prices. It is essential to consult with a healthcare provider or pharmacist to determine the actual cost of the medication. [6]

Sources:

[1] https://www.drugpatentwatch.com/drug/isavuconazonium-sulfate

[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445551/

[3] https://www.clinicaltrials.gov/ct2/show/NCT00444089

[4] https://www.accessdata.fda.gov/drugsatfdadocs/label/2015/206124s000lbl.pdf

[5] https://www.accessdata.fda.gov/drugsatfdadocs/nda/2015/206124Orig1s000Approv.pdf

[6] https://www.goodrx.com/crespemma