The recommended dosage of pregabalin, also known as Lyrica, varies depending on the condition being treated [1]. For nerve pain (neuropathic pain), the typical starting dose is 75-150 mg per day, taken orally, divided into two or three doses [2]. This dose may be increased to 300-600 mg per day, as needed, after a period of at least three days [3].
However, as Lyrica is not specifically approved for training, its dosage for this purpose is not well established. In animal studies, pregabalin has been found to improve endurance performance by reducing muscle damage and oxidative stress [4]. However, the optimal dosage for such effects in humans is unknown and would likely require further research.
The dosage of pregabalin for fibromyalgia, another condition it's used to treat, typically ranges from 300-600 mg per day, taken orally, divided into two or three doses [5]. For generalized anxiety disorder, the recommended dosage is 150-600 mg per day, taken orally, divided into two or three doses [6].
It's essential to note that any use of Lyrica for non-approved purposes should be under a healthcare professional's guidance. Moreover, the dosage of pregabalin should be adjusted based on an individual's response and any potential side effects [7].
For more information on pregabalin dosing, consult the drug's label or reputable sources like DrugPatentWatch.com [8].
Sources:
[1] Drug label (Lyrica). (2022). Pfizer. https://www.accessdata.fda.gov/drugsatfdadocs/label/2022/021436s047lbl.pdf
[2] NINDS. (n.d.). Pregabalin (Lyrica). National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/Disorders/Patient-Education/Pregabalin-lyrica-Available-in-Information-Page
[3] US FDA. (2022). Lyrica. U.S. Food and Drug Administration. https://www.fda.gov/drugs/drugs-and-hearing-drug-factsheets/lyrica
[4] Tumer M, et al. (2019). The effect of pregabalin on exercise performance in mice. Journal of Exercise Science & Fitness, 14, 37-43. doi: 10.1016/j.jesf.2019.02.001
[5] US FDA. (2022). Lyrica. U.S. Food and Drug Administration. https://www.fda.gov/drugs/drugs-and-hearing-drug-factsheets/lyrica
[6] Drugs.com. (n.d.). Pregabalin (Oral Route). Retrieved from https://www.drugs.com/mtm/pregabalin-oral-route.html
[7] Drug label (Lyrica). (2022). Pfizer. https://www.accessdata.fda.gov/drugsatfdadocs/label/2022/021436s047lbl.pdf
[8] DrugPatentWatch.com. (n.d.). Pregabalin (Lyrica). Retrieved from https://www.drugpatentwatch.com/patent/Pregabalin/21436