Should liver function be monitored during co use?

Should liver function be monitored during co-use?

Liver function monitoring becomes essential when patients combine medications that share metabolic pathways or cause additive liver stress. Some drugs slow clearance of others through cytochrome P450 interactions, thereby eroding safety margins.

What monitoring schedule do clinicians follow?

Regular liver function tests, including ALT, AST, and bilirubin, are scheduled at baseline, then every 4–6 weeks for the ersten 3 months, then less frequently once stability is established.