What's the recommended dosage of tigecycline with antacids?

Short answer: The tigecycline dose itself isn’t changed by taking antacids. But you should separate administration of tigecycline from antacids containing polyvalent cations (like calcium, aluminum, magnesium, or iron), because these can lower tigecycline exposure.

What to do about timing:
- Do not give tigecycline at the same time as the antacid.
- If you’re using an antacid, dose tigecycline either at least 2 hours before the antacid or at least 4 hours after the antacid.

Standard dosing for adults (IV; indications include complicated intra-abdominal infections, complicated skin and skin structure infections, and community-acquired pneumonia):
- Loading dose: 100 mg IV initially
- Maintenance: 50 mg IV every 12 hours
- Typical duration: 4–14 days for cIAI/cSSSI; 5–14 days for CAP (duration depends on infection type and response)

Notes:
- No dose adjustment is required for mild to moderate hepatic impairment; data are limited for severe hepatic impairment.
- Tigecycline has a boxed warning about use when alternatives are available due to mortality risk; this guidance is for clinicians, not a specific interaction with antacids.

If you have a specific infection type, other meds, or liver/kidney issues, tell me and I can tailor the details. And always follow your clinician’s instructions.