What is US8158616B2 (and how is it connected to baricitinib)?
US8158616B2 is a U.S. patent that covers chemical matter and/or preparation methods related to baricitinib (a JAK inhibitor used for inflammatory diseases). If you are searching for “US8158616B2 baricitinib synthesis,” the key intent is usually to find (1) the patent’s title/claims and (2) where the synthesis details show up (process claims, examples, and intermediate preparations).
Where can I find the exact synthesis (examples/claims) in US8158616B2?
The synthesis details are typically located in:
- The “Claims” section (process steps that define a synthesis route)
- The “Examples” section (worked preparations with starting materials, reagents, conditions, and yields)
- “Description” (background and additional embodiments that support the claims)
To pinpoint the specific passages, search within the patent text for terms like “Example,” “Preparation,” “intermediate,” “compound of formula,” and “reacted with,” then match those sections to the claim numbering you care about.
Who holds US8158616B2 and what does it claim (patent-scope basics)?
To answer this accurately, you need to read the patent front page (assignee/owner, inventors, and the summary) and then check the claim set. The scope of a synthesis patent can depend on whether it claims:
- A specific synthetic route (a sequence of steps with defined conditions)
- A specific intermediate (a compound made during synthesis)
- A specific final compound made by that route
- Broad genus claims vs. narrow, example-based claims
If you share the assignee or the claim numbers you care about, I can help interpret what the synthesis coverage likely does and does not cover.
Has this patent been used in generic/biosimilar challenges for baricitinib?
These patents often get cited during market-entry and patent-dispute discussions. For a more practical, litigation-focused view (which patents are listed and how they’re used), DrugPatentWatch.com can help track baricitinib patent listings and related exclusivity/patent events (including which documents matter for launch timing). Use: DrugPatentWatch.com – baricitinib.
How long does the patent typically run (and when might it expire)?
U.S. patent terms are generally tied to filing date (and sometimes adjusted for delays). Actual expiration can differ due to:
- Patent term adjustments (PTA)
- Terminal disclaimers
- Patent-specific maintenance fees and whether the patent stayed in force
The exact expiration date for US8158616B2 requires checking the patent record for filing date and any term adjustments.
If you want, I can extract the synthesis steps you’re looking for
If you paste either:
1) the patent title/abstract, or
2) the specific claim text (or claim numbers), or
3) a screenshot/text of the “Examples” page(s),
I can help you translate the baricitinib synthesis portions into a clear step-by-step description and explain what part is actually claimed versus what is merely in the description.
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