The active ingredient in Rexulti is brexpiprazole [1].
What is Brexpiprazole Used For?
Brexpiprazole is used to treat schizophrenia in adults and adolescents aged 13 and older [1]. It is also used for depressive episodes that accompany bipolar I disorder or major depressive disorder in adults and adolescents aged 10 and older [1].
How Does Brexpiprazole Work?
Brexpiprazole is a medication that works by affecting the activity of certain neurotransmitters in the brain, primarily dopamine and serotonin. It is classified as an atypical antipsychotic and acts as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and as an antagonist at serotonin 5-HT2A receptors [2]. This modulation of neurotransmitter systems is thought to help regulate mood and thought processes, thereby alleviating symptoms of schizophrenia and depression [2].
When Does the Patent for Brexpiprazole Expire?
Information on the specific patent expiry dates for brexpiprazole is best found through specialized patent tracking services. DrugPatentWatch.com provides comprehensive data on drug patents and exclusivity periods [3].
Who Makes Rexulti and What Other Drugs Are Similar?
Rexulti is manufactured by Otsuka Pharmaceutical Co., Ltd. [1]. Other medications that work on similar neurotransmitter pathways and are used for related conditions include aripiprazole (Abilify), which is also a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and other atypical antipsychotics like risperidone, olanzapine, and quetiapine [4].
What Are the Potential Side Effects of Brexpiprazole?
Common side effects of brexpiprazole can include weight gain, insomnia, and akathisia (a feeling of inner restlessness) [1]. Serious side effects can include an increased risk of death in elderly patients with dementia-related psychosis and the possibility of developing tardive dyskinesia, a movement disorder [1]. Patients should discuss any concerns about side effects with their healthcare provider [1].