Does fluconazole have sulfa in it?

No. Fluconazole does not contain a sulfa (sulfonamide) group. It is a triazole antifungal and is not considered a sulfa drug.

If you have a known severe sulfa allergy, you can usually take fluconazole, but it’s fine to check with your doctor or pharmacist if you’re unsure. If you’ve had a very serious reaction to sulfa medications, mention it to your clinician before starting fluconazole. If you want, tell me what meds you’re taking and I can help check for interactions.