Diclofenac injection indication?

Diclofenac Injection – Therapeutic Indications

Diclofenac sodium (the most commonly available injectable form) is a non‑steroidal anti‑inflammatory drug (NSAID) that provides rapid pain relief and reduces inflammation. The intramuscular (IM), intravenous (IV), or subcutaneous (SC) routes are used in situations where oral therapy is inadequate, contraindicated, or would be too slow to act.

How the Injection Works

• Rapid absorption: IV or IM administration bypasses the gastrointestinal tract, producing peak plasma concentrations within minutes.
• Anti‑inflammatory effect: Inhibits cyclooxygenase‑1 (COX‑1) and COX‑2, reducing prostaglandin synthesis at the site of inflammation.
• Analgesic effect: Lowers prostaglandin‑mediated sensitization of pain receptors.

Typical Dosage (varies by formulation & local guidelines)

• Intramuscular: 25–50 mg (often in a 2 mL solution) every 6–12 h, usually not exceeding 4 days.
• Intravenous: 25 mg IV push or infusion over 15–30 min; repeat dose based on response and tolerance.
• Subcutaneous: 50 mg in 1 mL; typically given 2–3 times per day.

Why Use Injection?

• Rapid onset when immediate pain control is needed.
• Bypasses GI tract in patients with nausea, vomiting, or swallowing difficulties.
• Short‑course therapy for acute flares where prolonged oral therapy is unnecessary or risky.

Important Considerations

• Contraindications: Uncontrolled hypertension, active GI ulcers, severe renal impairment, or known hypersensitivity.
• Side‑effects: GI upset, bleeding, renal dysfunction, cardiovascular events.
• Monitoring: Vital signs, renal function, and platelet count if used beyond a few days.

Bottom line: Diclofenac injection is primarily used for acute pain and inflammation—especially postoperative pain, trauma, gout flares, and short‑term management of inflammatory arthritis—providing rapid relief when oral NSAIDs are unsuitable or too slow to act.