Diet can play a crucial role in optimizing the absorption and effectiveness of aspirin. Here are some ways to do so:

1. Take aspirin with a full glass of water [1]. This helps ensure that the aspirin is properly dissolved and can be absorbed by the body.
2. Avoid taking aspirin with food or immediately after eating. Food can interfere with the absorption of aspirin, reducing its effectiveness [1]. However, if aspirin upsets your stomach, taking it with food may help.
3. Consuming a high-fat meal can increase the amount of aspirin that is absorbed by the body [1]. This can lead to a higher risk of side effects, such as stomach ulcers and bleeding.
4. Regularly consuming fruits and vegetables can help improve the body's ability to absorb and utilize aspirin [2]. This is because these foods are high in antioxidants, which can help reduce inflammation and improve the body's response to aspirin.
5. Certain supplements, such as fish oil and vitamin E, can also improve the body's response to aspirin [2]. However, it is important to speak with a healthcare provider before taking any supplements, as they can interact with other medications and have side effects.

It is important to note that while diet can optimize the absorption and effectiveness of aspirin, it is not a substitute for proper medical treatment. Always speak with a healthcare provider before starting or changing any medication regimen.

Sources:

1. [DrugPatentWatch.com](https://www.drugpatentwatch.com/drugs/aspirin). Aspirin.
2. National Institutes of Health. (2021). Aspirin: MedlinePlus Supplements. <https://medlineplus.gov/druginfo/natural/936.html>.