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Promethazine DM Syrup (Promethazine + Dextromethorphan) – Typical Adult Dose | Medication | Concentration in the syrup* | Typical adult dose | Frequency | Max daily volume | |------------|---------------------------|--------------------|-----------|-------------------| | Promethazine | 12.5 mg per 1 mL | 4.5 mL (≈56 mg) | Every 4–6 h as needed | 18 mL (≈120 mg) | | Dextromethorphan | 30 mg per 1 mL | 4.5 mL (≈135 mg) | Every 4–6 h as needed | 18 mL (≈540 mg) | *Promethazine DM syrup is usually 12.5 mg of promethazine and 30 mg of dextromethorphan per milliliter. How to take 1. Measure: Use a syringe, medicine cup, or the dosing tip that comes with the bottle. 2. Dose: Take 4.5 mL (about a full dose) by mouth, every 4–6 hours as needed for cough or allergy symptoms. 3. Limit: Do not exceed 18 mL in a 24‑hour period. 4. Timing: If you take it with food, the absorption may be a little slower but the effect is the same. Things to keep in mind - Sedation & dizziness are common; avoid driving or operating heavy machinery until you know how the drug affects you. - Respiratory depression risk is higher if you combine with alcohol, opioids, or other CNS depressants. - Contraindicated in patients with severe liver disease, severe asthma, or certain heart conditions. - Not for use in children under 6 unless specifically directed by a pediatrician (some formulations are pediatric, but dosing differs). When to seek help - Severe allergic reaction (hives, swelling, difficulty breathing). - Unusual drowsiness, confusion, or breathing problems. - If you accidentally take more than the maximum daily amount. Bottom line - Adult dose: 4.5 mL every 4–6 hours as needed, max 18 mL/24 h. - Always read the label, use the provided measuring device, and follow your healthcare provider’s instructions. If you’re unsure or have other medications, double‑check with a pharmacist or doctor.
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