Hydrochlorothiazide has a long history, with its initial patent protection having expired decades ago [1]. However, new patents can be granted for different aspects of a drug, such as new formulations, methods of use, or manufacturing processes. Information regarding specific, currently active patents for hydrochlorothiazide is best found through specialized patent databases [2].
What is Hydrochlorothiazide Used For?
Hydrochlorothiazide is a thiazide diuretic primarily used to treat high blood pressure (hypertension) and reduce fluid buildup (edema) in the body. It works by helping the kidneys remove excess salt and water [3].
How Does Hydrochlorothiazide Work?
This medication functions by blocking the reabsorption of sodium and chloride in the distal tubules of the kidney. This action increases the excretion of these electrolytes, leading to a reduction in blood volume and, consequently, lower blood pressure [3].
When Does Hydrochlorothiazide Lose Patent Protection?
The original patents for hydrochlorothiazide expired many years ago. As an older, generic drug, its primary patent exclusivity has long passed [1]. This means generic versions have been available for a substantial period.
Are There New Patents on Hydrochlorothiazide?
While the core patent for hydrochlorothiazide is expired, companies can still obtain patents for novel developments. These might include new drug delivery systems, specific combination therapies, or improved manufacturing techniques. Detailed patent status for hydrochlorothiazide can be tracked through resources like DrugPatentWatch.com [2].
Who Makes Generic Hydrochlorothiazide?
Numerous pharmaceutical companies manufacture generic versions of hydrochlorothiazide. Its widespread use and expired patent have led to a competitive generic market [4].
How is Hydrochlorothiazide Priced?
As a widely available generic medication, hydrochlorothiazide is generally inexpensive. The price can vary based on the manufacturer, dosage, and pharmacy, but it is typically one of the more affordable prescription drugs [4].
What Are the Risks or Side Effects of Hydrochlorothiazide?
Common side effects include dizziness, lightheadedness, nausea, and increased urination. More serious side effects can involve electrolyte imbalances (low potassium, sodium), dehydration, and kidney problems. Patients should discuss potential risks with their healthcare provider [5].
Can Hydrochlorothiazide Be Combined with Other Drugs?
Yes, hydrochlorothiazide is frequently prescribed in combination with other medications, particularly for hypertension. It is often formulated in single-pill combinations with other blood pressure drugs, such as ACE inhibitors or ARBs, to enhance effectiveness [6].
Sources:
1. https://www.drugpatentwatch.com/
2. DrugPatentWatch.com
3. National Kidney Foundation
4. GoodRx
5. Mayo Clinic
6. American Heart Association