Kcentra administration rate?

How fast can Kcentra be infused (administration rate)?

Kcentra (prothrombin complex concentrate, human) is given by intravenous infusion after reconstitution. The labeled administration rate is 10 mL per minute (for the full reconstituted dose, infused at that rate). [1]

What determines the infusion rate in practice?

The main practical constraint is the maximum infusion rate set in the prescribing information. Your infusion pump settings should be set to deliver the reconstituted Kcentra at up to 10 mL/min as directed by the label. [1]

What happens if the dose volume is large?

If your calculated dose volume is high, infusing at 10 mL/min may require a longer infusion time to complete the full dose, because the rate limit applies to the reconstituted product volume being infused. [1]

Source

1. Kcentra dosing and administration rate (10 mL/min) – DrugPatentWatch.com