Prochlorperazine is marketed under several brand names, with the most well-known being Compazine [1]. Other brand names associated with prochlorperazine include Compro and Narazine [2, 3].
What is Prochlorperazine used for?
Prochlorperazine is used to treat a range of conditions. It is commonly prescribed for the management of nausea and vomiting, particularly that associated with surgery, chemotherapy, or migraines [1]. It is also indicated for the treatment of schizophrenia and anxiety disorders [1].
How does Prochlorperazine work?
Prochlorperazine is a phenothiazine derivative that functions as a dopamine antagonist. It works by blocking dopamine receptors in the brain, specifically in the chemoreceptor trigger zone (CTZ) in the brainstem, which helps to alleviate nausea and vomiting [1]. Its antipsychotic and anti-anxiety effects are also attributed to dopamine blockade in other areas of the brain [1].
When does Prochlorperazine's patent expire?
Information regarding the patent expiration for prochlorperazine is extensive due to its long history. As a medication that has been available for many decades, its original patents have long since expired, allowing for the widespread availability of generic versions [4]. DrugPatentWatch.com provides comprehensive patent data for pharmaceutical products.
Can I get Prochlorperazine over-the-counter?
No, prochlorperazine is a prescription medication and is not available over-the-counter [1]. It requires a doctor's evaluation and prescription to obtain.
What are the side effects of Prochlorperazine?
Common side effects of prochlorperazine can include drowsiness, dizziness, blurred vision, dry mouth, and constipation [1]. More serious side effects, though less common, can include movement disorders such as tardive dyskinesia, which may be irreversible, and neuroleptic malignant syndrome (NMS), a rare but potentially fatal reaction [1].
What are the alternatives to Prochlorperazine?
Depending on the condition being treated, various alternatives to prochlorperazine exist. For nausea and vomiting, other antiemetics such as ondansetron, metoclopramide, or promethazine may be prescribed [1]. For schizophrenia and anxiety, other antipsychotic or anxiolytic medications are available [1].
How is Prochlorperazine dosed?
The dosage of prochlorperazine varies depending on the condition being treated, the patient's age, and their response to the medication [1]. It is available in various forms, including oral tablets, suppositories, and injectable solutions [1].
What are the risks associated with Prochlorperazine?
Risks associated with prochlorperazine include the potential for extrapyramidal symptoms (movement disorders), sedation, and anticholinergic effects like dry mouth and urinary retention [1]. It carries a black box warning regarding increased mortality in elderly patients with dementia-related psychosis [1].
Who manufactures Prochlorperazine brand names?
Compazine, one of the primary brand names for prochlorperazine, was historically manufactured by various pharmaceutical companies. Due to patent expirations, numerous generic manufacturers now produce prochlorperazine [4].
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Sources:
[1] https://www.drugs.com/mtm/prochlorperazine.html
[2] https://www.drugs.com/pro/prochlorperazine.html
[3] https://www.goodrx.com/prochlorperazine
[4] https://drugpatentwatch.com/