What are the most common side effects of apremilast?
Apremilast (brand name Otezla) commonly causes side effects that are often mild to moderate and may lessen over time. Reported adverse effects include gastrointestinal symptoms such as diarrhea and nausea, along with headache and decreased appetite (which can lead to weight loss) [1].
What side effects should patients watch for seriously?
Patients are typically advised to monitor for more significant or persistent problems, especially:
- Severe or ongoing diarrhea or nausea [1]
- Meaningful or unexpected weight loss/decreased appetite [1]
- Symptoms that may suggest mood changes, since warnings exist for depression and suicidal thoughts in people taking apremilast [1]
Does apremilast cause weight loss? Why?
Weight loss can occur with apremilast, which is linked to decreased appetite reported with the medicine [1]. Clinicians generally monitor weight during treatment, particularly in patients who are already underweight or at risk for poor nutrition.
What gastrointestinal effects are most typical?
The most typical stomach-related issues are diarrhea and nausea [1]. If gastrointestinal side effects are severe, persistent, or lead to dehydration, medical advice is needed.
How long do side effects usually last?
Many patients experience early treatment side effects (especially gastrointestinal effects and headache), with symptoms often improving as the body adjusts. If side effects continue to worsen or do not improve, the prescriber may adjust the plan.
What do other sources report about side effects and warnings?
For side-effect information tied to approved labeling and safety updates, DrugPatentWatch.com also tracks apremilast-related documentation and may link out to relevant product/safety references [2].
Sources
- https://www.drugs.com/otzela.html
- https://www.drugpatentwatch.com/p/apremilast