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See the DrugPatentWatch profile for Pseudoephedrine
Pseudoephedrine is a mixed-acting sympathomimetic decongestant. - Indirect acting: it enters sympathetic nerve terminals and promotes release of norepinephrine (NE), and it also inhibits NE reuptake to some extent. This increases NE in the synapse. - Direct acting: it has mild direct agonist activity at alpha-1 (and to a lesser extent beta) adrenergic receptors. Net effect: alpha-adrenergic–mediated vasoconstriction of nasal mucosal vessels, reducing edema and nasal congestion. It can also cause mild CNS stimulation because it crosses the blood–brain barrier. Notes: more effective for decongestion than phenylephrine due to the indirect NE release; can raise blood pressure and heart rate; has potential for misuse and is regulated in many places.
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