Half life of lokelma?

There isn’t a traditional half-life for Lokelma. Sodium zirconium cyclosilicate (Lokelma) is not absorbed from the GI tract, so there is negligible systemic exposure and no plasma elimination half-life. It acts locally in the gut and is excreted unchanged in the feces.

If you’re looking for pharmacokinetic details: the concept of half-life isn’t applicable here because the drug isn’t circulating in the blood. If you’d like, I can share information about onset of effect or dosing considerations.