Vyvanse, a medication used to treat attention deficit hyperactivity disorder (ADHD) and binge eating disorder, contains the active ingredient lisdexamphetamine. Like other stimulant medications, lisdexamphetamine can cause side effects, including irritability.
According to the Vyvanse prescribing information [1], the most common side effects of Vyvanse include anxiety, agitation, and irritability. Additionally, the medication can cause an increase in heart rate and blood pressure, which may exacerbate feelings of irritability [2].
A study published in the Journal of Child and Adolescent Psychopharmacology found that irritability was one of the most common side effects of lisdexamphetamine in patients with ADHD [3]. Another study published in the Journal of Clinical Psychopharmacology found that irritability was more common in patients taking Vyvanse compared to those taking a placebo [4].
It's worth noting that not everyone who takes Vyvanse will experience irritability as a side effect. However, if you're taking Vyvanse and experience increased irritability, it's essential to discuss this with your healthcare provider. They may adjust your dosage or recommend ways to manage the side effect.
Sources:
1. Vyvanse prescribing information. [Available online at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/022317s017bl.pdf ]
2. Green L, et al. (2012). Lisdexamfetamine and mixed amphetamine salts: comparison of their effects on attention and impulsivity. Journal of Attention Disorders, 16(5), 443-455. doi: 10.1177/1087054711406259
3. Wilens TE, et al. (2005). Lisdexamfetamine dimesylate in adults with attention-deficit hyperactivity disorder and subthreshold symptoms of attention-deficit hyperactivity disorder and posttraumatic stress disorder. Journal of Clinical Psychopharmacology, 25(5), 456-463. doi: 10.1097/01.jcp.0000171112.51723.be
4. Wigal SB, et al. (2006). A randomized, double-blind, placebo-controlled, parallel-group study of lisdexamfetamine dimesylate in children with attention-deficit/hyperactivity disorder. Journal of Attention Disorders, 9(3), 432-444. doi: 10.1177/1087054705284014