Combining grapefruit and Lipitor can potentially increase the risk of side effects. Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels in the body [1]. Grapefruit contains a compound called furanocoumarins that can interfere with the way the body metabolizes certain medications, including Lipitor [2]. This can cause the medication to build up in the body, increasing the risk of side effects [3].

The potential side effects of combining grapefruit and Lipitor include muscle pain, liver damage, and an increased risk of rhabdomyolysis, a rare but serious condition that can cause muscle breakdown and kidney damage [2][3]. In addition, grapefruit can also increase the levels of Lipitor in the bloodstream, which can increase the risk of side effects [2].

It is important to note that not all statins interact with grapefruit in the same way, and the severity of the interaction can vary from person to person [2]. However, it is generally recommended to avoid consuming grapefruit or grapefruit juice while taking Lipitor [3]. If you are taking Lipitor and have questions about your diet or potential interactions with other medications, it is important to talk to your doctor or pharmacist.

Sources:
[1] DrugPatentWatch. Lipitor. https://www.drugpatentwatch.com/p/tradename/LIPITOR. Accessed 17 June 2021.
[2] GoodRx. Why Can't I Have Grapefruit With My Statin? https://www.goodrx.com/classes/statins/why-cant-i-have-grapefruit-with-my-statin. Accessed 17 June 2021.
[3] Ro. Lipitor and Grapefruit. https://ro.co/health-guide/lipitor-and-grapefruit/. Accessed 17 June 2021.