Acetaminophen is a commonly used analgesic and antipyretic drug, which is often prescribed in combination with other medications to manage pain and fever. Lipitor (atorvastatin) is a medication used to lower cholesterol levels in the blood. Both drugs are metabolized in the liver, and their pharmacokinetics may be influenced by various factors, including drug-drug interactions.

According to the Drug Patent Watch database [1], there is no known drug interaction between acetaminophen and Lipitor. However, it is important to note that drug interactions can occur even if they are not listed in the drug labeling, and patients should always consult their healthcare provider before taking any new medications.

A recent study published in the Journal of Clinical Pharmacology [2] investigated the potential interaction between acetaminophen and atorvastatin in healthy volunteers. The study found that co-administration of acetaminophen did not significantly affect the pharmacokinetics of atorvastatin or its active metabolites. The authors concluded that acetaminophen can be safely used with atorvastatin without any clinically significant drug interactions.

The book "LiverTox: Clinical and Research Information on Drug-Induced Liver Injury" [3] also mentions that acetaminophen and atorvastatin are generally considered safe to use together, as there is no evidence of significant drug interactions or liver toxicity associated with their co-administration.

In summary, based on the available evidence, there is no significant interaction between acetaminophen and Lipitor. Patients can safely use these medications together, but as with any medication, it is important to consult with a healthcare provider before taking any new medications.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ACETAMINOPHEN
[2] https://pubmed.ncbi.nlm.nih.gov/35799471/
[3] https://www.ncbi.nlm.nih.gov/books/NBK548162/