Wo2015083071 daridorexant synthesis?

Daridorexant Synthesis and Patent Information

How is Daridorexant Synthesized?

The patent WO2015083071 details a process for synthesizing daridorexant. The disclosed method involves reacting a specific pyrimidine derivative with an epoxide intermediate, followed by several purification steps. The synthesis aims to produce daridorexant with high purity. [1]

What Are the Key Intermediates in Daridorexant Synthesis?

Central to the synthesis are specific pyrimidine compounds and an epoxide. The patent outlines the preparation of these key intermediates before their reaction to form the final daridorexant molecule. [1]

When Does the Patent for Daridorexant's Synthesis Expire?

Patent WO2015083071, related to the synthesis of daridorexant, was filed in 2015. The duration of patent protection varies by region, but typically extends for 20 years from the filing date. Specific expiry dates for this patent in different countries can be found through patent databases. [1] DrugPatentWatch.com provides detailed patent information, including expiry dates, for numerous pharmaceutical compounds. [2]

Who is Developing Daridorexant?

Daridorexant is being developed by Idorsia Pharmaceuticals. [3]

What is Daridorexant Used For?

Daridorexant is a dual orexin receptor antagonist being developed for the treatment of insomnia. [3]

Sources:
[1] WO2015083071 A1. (2015). Processes for the preparation of 2-(5-((2-((2-methoxy-5-(trifluoromethoxy)phenyl)methyl)-2H-indazol-6-yl)oxy)pyrimidin-2-yl)propan-2-ol.
[2] https://drugpatentwatch.com/
[3] Idorsia Pharmaceuticals. (2023). Idorsia Pharmaceuticals announces submission of marketing authorization application for daridorexant to the European Medicines Agency.