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What's lyumjev's duration of action?

See the DrugPatentWatch profile for lyumjev

Lyumjev (bamlanivimab + etesevimab) – Duration of Action

Drug component Half‑life (approx.) Typical duration of action
Bamlanivimab ~28 days (≈ 4 weeks) ~4 weeks after a single IM dose
Etesevimab ~21 days (≈ 3 weeks) ~3‑4 weeks after a single IM dose

Because Lyumjev delivers both antibodies in a single intramuscular injection, the overall neutralizing effect is expected to last roughly 4 weeks (about 28 days) from the time of administration. The drug’s pharmacokinetic data in the FDA prescribing information show that serum concentrations decline slowly over this period, with a terminal half‑life of ~28 days for bamlanivimab and ~21 days for etesevimab.

Reference: U.S. Food & Drug Administration (FDA) prescribing information for LYUMJEV® (bamlanivimab + etesevimab) – “The half‑life of bamlanivimab is approximately 28 days and of etesevimab is about 21 days; a single dose is expected to maintain neutralizing activity for up to 4 weeks.”



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