Can Keppra (levetiracetam) cause mood swings?
Yes. Keppra can cause mood-related side effects, including irritability, agitation, anger, and mood swings. These effects are reported in the prescribing information and are a known part of Keppra’s safety profile for some people. [1]
What kinds of mood changes are most commonly reported?
Patients and clinicians most often describe behavioral or emotional changes such as:
- Irritability or sudden changes in mood
- Aggression/anger or hostility
- Agitation/restlessness
- Anxiety or depression (in some cases)
Because the symptoms can show up as “personality” or “behavior” changes, mood swings can be noticed by family or caregivers as well as by the person taking the medicine. [1]
How soon after starting Keppra can mood swings happen?
Mood and behavior changes can occur after starting Keppra and can also change over time as the dose changes. If symptoms begin soon after the start or after an increase in dose, that timing is an important clue for clinicians. [1]
What should you do if mood swings show up?
If mood swings, irritability, or aggressive behavior develop, contact your prescriber promptly. Clinicians may:
- Check whether Keppra dosing needs adjustment
- Consider dose reduction or discontinuation
- Consider alternative seizure medicines if symptoms are significant or persistent [1]
Get urgent help if there are signs of severe depression, suicidal thoughts, or dangerous aggression.
Are mood changes more likely with higher doses?
Mood and behavior side effects are more likely to be noticed when the total exposure is higher (for example, after dose increases). The key action is still to involve your prescriber rather than changing the dose on your own. [1]
Can Keppra mood side effects be mistaken for something else?
Yes. Worsening mood can also come from:
- The underlying neurologic condition or seizures
- Sleep problems, stress, or other medications
- Other medical causes
But because Keppra is specifically associated with these behavioral effects, prescribers typically look for a temporal link to starting or changing Keppra. [1]
---
Sources
[1] https://www.drugs.com/monograph/keppra.html