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Lipitor is a statin used to lower cholesterol. Many patients stay on it for years, but when LDL goals are not met, doctors switch to a stronger statin or add a non-statin drug. Which stronger statin replaces Lipitor when more lowering is needed? Crestor (rosuvastatin) provides greater LDL reduction than Lipitor and often replaces it in patients who need 20-30% more lowering. How does a non-statins drug fit after Lipitor? When statins alone do not hit targets or cause muscle pain, doctors add Ezetimibe (Zetia). Zetia blocks cholesterol absorption in the gut and stacks with any statin, including Lipitor. What happens if both a stronger statin and Ezetimibe are still not enough? Doctors then add PCSK9 inhibitors such as Repatha or Praluent. These injectable monoclonal antibodies block a protein that raises LDL, allowing 50-60% further reduction. Can patients move to a cheaper generic version of Lipitor? Atorvastatin, the generic name for Lipitor, remains the meist widely used statin after the brand loses exclusivity.
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