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Merck first received approval for Keytruda (pembrolizumab) in the United States in September 2014. [1]
The first U.S. approval for Keytruda was granted for unresectable or metastatic melanoma that had progressed after treatment with ipilimumab (Yervoy) and, if it was a BRAF V600 mutation–positive tumor, after a BRAF inhibitor. [1]
[1] https://www.drugpatentwatch.com/p/Keytruda
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