How often should i apply xerese?

Recommended Application Frequency for Xerese

Apply Xerese (acyclovir 5% and hydrocortisone 1% cream) to the affected area 5 times daily. Space applications evenly throughout the day, about every 3-4 hours while awake.[1]

How to Apply It Correctly

Use a clean finger to apply a thin layer covering the cold sore or lesion and 0.5 inches of surrounding skin. Start treatment at the first sign of symptoms, like tingling or itching. Wash hands before and after. Continue for 5 days or as directed by your doctor.[1][2]

What Happens If You Miss a Dose or Overapply

Apply the missed dose as soon as you remember, then resume the schedule. Do not double up. Overuse risks more skin irritation or reduced effectiveness; stick to 5 times daily max.[1]

How Long Until It Works and Treatment Duration

Symptoms often improve within 4-5 days of starting. Full treatment course is typically 5 days—stopping early may lead to recurrence. Consult a doctor if no improvement after 5 days.[2]

Who Should Avoid or Adjust Frequency

Not for children under 12, or those with weakened immune systems without doctor approval. Use caution if pregnant/breastfeeding; apply less frequently if irritation occurs. Always check with a healthcare provider for personalized dosing.[1]

[1]: Xerese Prescribing Information (Medscape)
[2]: DailyMed FDA Label for Xerese