Yes, Lurbinectedin has been linked to several side effects. According to the drug's prescribing information, the most common adverse reactions include fatigue, nausea, decreased appetite, vomiting, constipation, and diarrhea [1]. Additionally, laboratory abnormalities such as decreased neutrophil counts, decreased lymphocyte counts, and increased liver enzymes have also been reported [1].

Moreover, a study published in the Journal of Clinical Oncology reported that serious adverse events occurred in 42% of patients treated with Lurbinectedin, with the most common being neutropenia, febrile neutropenia, and thrombocytopenia [2]. The study also noted that 10% of patients discontinued treatment due to adverse events [2].

It is important to note that Lurbinectedin is a relatively new drug, and its long-term side effects are not yet fully understood. Therefore, patients should be closely monitored for any adverse reactions during treatment [1].

In summary, Lurbinectedin has been linked to several side effects, including fatigue, nausea, decreased appetite, vomiting, constipation, diarrhea, and laboratory abnormalities. Serious adverse events such as neutropenia, febrile neutropenia, and thrombocytopenia have also been reported [1][2].

Sources:

1. <https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/214437s000lbl.pdf>
2. <https://ascopubs.org/doi/full/10.1200/JCO.20.01345>
3. <https://www.drugpatentwatch.com/drugs/lurbinectedin>