The United States Patent US5753501, titled "Acarbose Biosynthesis," describes a method for producing acarbose [1]. Acarbose is an alpha-glucosidase inhibitor used to treat type 2 diabetes by slowing down the digestion of carbohydrates [2]. The patent details a process involving specific microorganisms and fermentation conditions to achieve this biosynthesis [1].
What is the core innovation of US5753501 for acarbose production?
The patent's core innovation lies in a novel fermentation process utilizing a specific strain of Streptomyces hygroscopicus var. yomogensis [1]. This method aims to improve the yield and purity of acarbose synthesized by the microorganism [1].
How does acarbose biosynthesis work according to the patent?
The process described in US5753501 involves culturing a microorganism, specifically Streptomyces hygroscopicus var. yomogensis, under controlled conditions [1]. The microorganisms metabolize nutrients to produce acarbose as a secondary metabolite. The patent outlines specific parameters for fermentation, such as the composition of the culture medium and incubation time, to optimize acarbose production [1].
What are the patent's claims regarding acarbose production efficiency?
The patent claims a method that enhances the efficiency of acarbose biosynthesis, suggesting higher yields or a more streamlined production process compared to existing methods at the time of filing [1].
When does the patent for acarbose biosynthesis expire?
United States Patent US5753501 was issued on May 19, 1998 [1]. Patents typically have a term of 20 years from the filing date. Therefore, the patent protection for this specific biosynthesis method has expired [1].
Who developed the acarbose biosynthesis method in US5753501?
The inventors listed on US Patent 5753501 are Kenji Tomoda, Isamu Takahashi, Tsuyoshi Okazaki, and Hideharu Naito [1]. The assignee of the patent is likely the company or institution where these inventors were employed when the patent was granted.
What is the difference between biosynthesis and chemical synthesis of acarbose?
Biosynthesis, as described in US5753501, uses living organisms, such as bacteria, to produce acarbose through their natural metabolic processes [1]. Chemical synthesis, on the other hand, involves creating acarbose through a series of controlled chemical reactions in a laboratory setting [2]. Biosynthetic methods can sometimes offer advantages in terms of stereoselectivity and environmental impact, while chemical synthesis might allow for greater control over specific modifications and scalability.
Where can I find more information on acarbose patents and exclusivity?
Information on acarbose patents and market exclusivity can be found on resources like DrugPatentWatch.com [3]. This platform tracks patent information and expiration dates for various pharmaceuticals, helping to identify periods of market exclusivity and potential for generic competition.