Lipitor is a medication used to lower cholesterol levels in the blood. It belongs to a class of drugs called statins, which work by inhibiting an enzyme involved in the production of cholesterol in the liver. According to the sources provided [1][2], Lipitor can be taken with or without food. However, high-fat meals can interfere with the absorption of Lipitor and reduce its effectiveness. Therefore, it is recommended to take Lipitor at the same time every day, with or without food, to maintain consistent blood levels of the drug. Patients should avoid consuming grapefruit or grapefruit juice while taking Lipitor, as it can increase the risk of side effects. In general, it is important to consult with a healthcare provider or pharmacist before taking Lipitor or any other medication, especially if there are concerns about food-drug interactions [3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.webmd.com/drugs/2/drug-3330/lipitor-oral/details
[3] https://www.uspharmacist.com/article/fooddrug-interactions