Does combining advil with tricyclics pose risks?

What happens if I take Advil with tricyclic antidepressants?

Taking Advil (ibuprofen) with tricyclic antidepressants (TCAs) can increase the risk of serious side effects, including bleeding and liver damage [1].

Why is the combination risky?

TCAs can slow down the heart rate, and combining them with ibuprofen, which can also slow down blood clotting, may increase the risk of bleeding [2]. Additionally, ibuprofen can raise liver enzyme levels, potentially interacting with TCAs, which can also cause liver damage.

Are there any specific tricyclic antidepressants to be cautious with?

Bupropion, a TCA, has been reported to cause liver damage when taken with ibuprofen [3]. Amoxapine, another TCA, has been associated with a higher risk of bleeding when combined with NSAIDs like ibuprofen.

Who is most at risk from these interactions?

Older adults and individuals with pre-existing liver or kidney disease may be more susceptible to the adverse effects of combining TCAs and ibuprofen.

How should you take your medications?

If you're taking TCAs and ibuprofen, consult your healthcare provider to discuss the potential risks and benefits of the combination. Monitor your liver function and bleeding risk closely if this combination is necessary. Inform your healthcare provider about any changes to your medications or other health conditions [4].

Sources:

[1] https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/adverse-drug-interactions-ibuprofen-tricyclic-antidepressants

[2] https://www.drugs.com/drug-interactions/ibuprofen/tricyclic-antidepressants.html#apply [1] (search results from DrugWatch)

[3] https://www.webmd.com/drugs/2/drug-1425/bupropion+hcl+tab/tablet/details

[4] https://www.medlineplus.gov/ency/article/001998.htm

https://www.drugpatentwatch.com