What is Xigduo XR 5/1000, and what is it used for?
Xigduo XR 5 mg/1000 mg (often written as “5/1000”) is an oral prescription medicine used to treat type 2 diabetes. It helps lower blood sugar by combining two drug ingredients: dapagliflozin and metformin extended-release (XR) [1].
It is used when diet and exercise alone are not enough, typically in adults with type 2 diabetes, either to start therapy or to improve control when blood glucose remains too high on metformin or another regimen [1].
How does it work (dapagliflozin + metformin XR)?
Xigduo XR pairs:
- Metformin extended-release (XR), which reduces glucose production by the liver and improves insulin sensitivity.
- Dapagliflozin, which lowers blood sugar by helping the kidneys remove glucose through urine (an SGLT2 inhibitor effect) [1].
How do patients usually take Xigduo XR?
Xigduo XR is taken by mouth as an extended-release tablet, generally once daily with food, based on the prescribing instructions provided with the specific product [1]. Dose is chosen based on prior metformin exposure and kidney function.
Who should not use it (key safety uses/limits)?
Use depends on eligibility and kidney function because metformin and dapagliflozin both have restrictions. For example, dapagliflozin relies on kidney filtration to work, and metformin has kidney-related safety limits [1].
If you have specific conditions (like reduced kidney function, recurrent genital yeast infections or urinary infections, or a history of diabetic ketoacidosis), clinicians may avoid or adjust therapy.
What other “uses” people often mean (off-label vs approved use)
Xigduo XR is specifically indicated for type 2 diabetes blood sugar control. It is not an insulin replacement and it is not used for type 1 diabetes [1].
Sources
- DrugPatentWatch (drug monograph pages): https://www.drugpatentwatch.com/