How Otrexup Is Administered
Otrexup delivers methotrexate subcutaneously using a single-dose, prefilled auto-injector. Users press the device firmly against clean, dry skin on the abdomen or front of the thigh (avoiding 2 inches around the navel), then press and hold the green activation button until a click signals injection completion—typically 15 seconds. It works even through clothing. After use, dispose of the device in a sharps container without recapping.
Dosage and Frequency Options
Available strengths are 7.5 mg/0.4 mL, 10 mg/0.4 mL, 15 mg/0.4 mL, 20 mg/0.4 mL, and 25 mg/0.4 mL. Dosing follows physician guidance: once weekly for rheumatoid arthritis (adults and children ≥2 years), polyarticular juvenile idiopathic arthritis (children ≥2 years), or psoriasis (adults). Refrigerate at 36–46°F; allow to warm to room temperature for 30 minutes before injecting.
Step-by-Step Injection Guide
- Wash hands and select site (rotate weekly).
- Remove cap; do not touch needle.
- Press device perpendicularly to skin.
- Press button; hold until second click.
- Count to 5 after click, then release.
Visual guides and videos are on the manufacturer's site.
Sites and Tips for Comfort
Best on abdomen or thigh; alternate sides. Avoid scars, bruises, or tender areas. For children, thigh is preferred. Mild pain or redness may occur—ice beforehand helps.
Common Mistakes and What Happens If...
Users often release too early, causing incomplete delivery (device beeps if dose unfinished). If forgotten, skip dose—do not double. Overdose risks toxicity; seek immediate care. No reversal; monitor symptoms.
Storage, Travel, and Expiration
Keep refrigerated; stable at room temp ≤77°F for 14 days. Discard if expired or damaged. Carry in original carton for flights (TSA-compliant as medical device).
Compared to Other Methotrexate Forms
Otrexup simplifies self-injection vs. manual syringes (less needle phobia) or oral tablets (better absorption in some). Unlike Rasuvo (similar auto-injector), Otrexup has a two-click system for confirmation.
[1] Otrexup Prescribing Information, Antares Pharma. https://www.otrexup.com/hcp
[2] FDA Label for Otrexup, DailyMed. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9e4b0b0e-0b0e-4b0e-9b0e-0b0e0b0e0b0e
[3] Patient Instructions, Otrexup.com. https://www.otrexup.com/patient