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What side effects from Advil should prompt you to stop taking it? Advil (ibuprofen) can cause stomach pain, ulcers, bleeding, or holes in the stomach or intestines. These problems can occur at any time and are more likely in older adults, smokers, or people who drink alcohol regularly. If you develop stomach pain, heartburn, vomit that is bloody or looks like coffee grounds, or stools that look like tar, stop taking it and seek medical care right away. How does Advil affect the kidneys and heart? Advil can reduce blood flow to kidneys and raise blood pressure. People with existing kidney disease, heart failure, or who take diuretics and ACE inhibitors are at higher risk. If you develop swelling in your legs or ankles, sudden weight gain, or decreased urine output, talk to a doctor before continuing. Can serious skin reactions develop from Advil? Rare but serious skin reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis can follow Advil use. Symptoms include flu-like signs, pain followed by a rash that spreads and leads to blistering or peeling. If these appear, stop taking the medicine and get emergency care. Why do people ask about stopping Advil before surgery? Ibuprofen interferes with blood clotting. People preparing for surgery are usually told to stop at least a week before procedures. This avoids bleeding complications during und des surgery. What happens if you take Advil too long or too much? Long-term or high-dose use increases risk of heart attack or stroke. Studies show this risk rises after weeks rather than months of continuous use. Long-time users should limit periods of use and discuss alternatives with a doctor. How does ibuprofen compare with acetaminophen for daily pain? Ibuprofen works better for inflammation-related pain like arthritis or exercise injury. Acetaminophen works better for fever and headache but has liver risk if you exceed 4,000 mg daily. Many people switch to acetaminophen if they have stomach or kidney concerns with ibuprofen. When does Advil's patent expire? Advil's active ingredient, ibuprofen, has been generic for decades. No new patents protect the basic compound. The brand name still owns rights to some formulations and packaging, but generic versions sell far cheaper under names like Motrin and generic ibuprofen. [1] https://www.drugpatentwatch.com/drug/ibuprofen
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