Does imbruvica interact with grapefruit juice?

What are the warnings around imbruvica and grapefruit juice?

If you take Imbruvica (ibrutinib), a medication used to treat various types of non-Hodgkin's lymphoma and mantle cell lymphoma, you should be aware of a potential interaction with grapefruit juice [1]. Consuming grapefruit or grapefruit juice while taking Imbruvica may lead to increased levels of the medication in your bloodstream, which can cause side effects [1].

Why does Imbruvica interact with grapefruit juice?

Grapefruit juice, particularly the furanocoumarin compound bergamottin, can affect the way Imbruvica is metabolized by your liver. This is called a Cytochrome P450 (CYP) 3A4 inhibition, which can lead to increased levels of ibrutinib in your body [2].

What are the risks of taking Imbruvica with grapefruit juice?

When you take Imbruvica with grapefruit juice, it may increase your risk of side effects, including:

* Increased risk of bleeding and bruising
* Increased risk of infection
* Elevated liver enzymes
* Diarrhea
* Abdominal pain
* Nausea and vomiting

What should I do?

To minimize the risk of interactions between Imbruvica and grapefruit juice:

* Avoid consuming grapefruit and grapefruit juice while taking Imbruvica.
* If you experience any adverse effects while taking Imbruvica, consult your healthcare provider immediately.
* Your healthcare provider may adjust your Imbruvica dosage if necessary.

Other cautions and considerations

If you experience any unusual side effects or have concerns about Imbruvica or grapefruit juice, consult your healthcare provider. They can provide personalized advice and monitoring to ensure your safety while taking Imbruvica [3].

[1] https://www.drugpatentwatch.com/drug/ibrutinib-imsyc-peptides-ibru-1/
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631119/
[3] Pfizer. (2022). Imbruvica (Ibrutinib) Label. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/206162s025lbl.pdf