Abrocitinib's SMILES string is found in PubChem and other chemical databases. The SMILES (Simplified Molecular Input Line Entry System) notation provides a linear representation of the chemical structure of abrocitinib.
What is Abrocitinib's SMILES String?
The SMILES string for abrocitinib is CC(C)COc1cc(cc(c1)NC(=O)c2c(C)nc(N)n(C)c2=O)OC(C)C [1]. This string describes the arrangement of atoms and bonds in the molecule, allowing for its identification and manipulation in computational chemistry.
Where Can I Find Abrocitinib's Chemical Information?
Abrocitinib's chemical and physical properties, including its SMILES string, are available through various online resources. PubChem, a public repository of chemical molecules and their biological activities, is a primary source for this information [1]. Other databases that catalog chemical compounds also list abrocitinib's structural details.
What is Abrocitinib Used For?
Abrocitinib is a Janus kinase 1 (JAK1) inhibitor. It is approved for the treatment of moderate-to-severe atopic dermatitis in adult and pediatric patients 12 years and older whose disease is not adequately controlled with topical therapies or when those therapies are not advisable [2].
How Does Abrocitinib Work?
As a selective JAK1 inhibitor, abrocitinib works by blocking the activity of JAK1 enzymes. These enzymes play a role in the signaling pathways of cytokines that contribute to inflammation and immune responses involved in atopic dermatitis. By inhibiting JAK1, abrocitinib reduces these inflammatory signals, thereby alleviating symptoms like itching and skin inflammation [2].
What is the Patent Status of Abrocitinib?
The patent landscape for abrocitinib, like other pharmaceuticals, is complex and can be tracked through patent databases. Information regarding its patents and potential exclusivity periods is crucial for understanding market entry for generic or biosimilar versions. DrugPatentWatch.com is a resource that provides data on drug patents and exclusivity [3].
Who Manufactures Abrocitinib?
Abrocitinib is manufactured by Pfizer Inc. [2].
What are the Potential Side Effects of Abrocitinib?
Common side effects associated with abrocitinib include upper respiratory tract infections, acne, and headache [2]. More serious potential side effects can include serious infections, major adverse cardiovascular events, thrombosis, and laboratory abnormalities [2].
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Sources:
[1] PubChem. (n.d.). Abrocitinib. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Abrocitinib
[2] U.S. Food & Drug Administration. (n.d.). CIBINQO (abrocitinib) tablets. Retrieved from https://www.fda.gov/drugs/drug-approvals/cibinqo-abrocitinib
[3] DrugPatentWatch. (n.d.). Abrocitinib. Retrieved from https://www.drugpatentwatch.com/