Can Rinvoq (upadacitinib) cause acne?
Yes. Rinvoq’s prescribing information lists acne as a possible skin-related side effect, including “acne” and acne-like eruptions. This means some people may develop new acne or a flare/worsening of existing acne while taking upadacitinib. [1]
What other skin problems should people watch for?
Alongside acne, JAK inhibitor treatment can be associated with other dermatologic effects, including rash and other skin reactions (the exact list depends on the specific labeling and study reports). Patients are generally advised to contact a clinician if they develop a new or worsening skin condition while on Rinvoq. [1]
How soon does acne appear after starting Rinvoq?
The timing of acne onset varies from person to person. For drug-related skin reactions, it can appear within the first weeks to months after starting therapy, but some cases occur later. If acne develops, monitoring and early treatment guidance from a clinician can help prevent it from becoming severe. [1]
What should patients do if acne appears?
If you develop acne while taking Rinvoq, common next steps include:
- Tell your prescriber or dermatologist so they can confirm it’s likely drug-related and recommend treatment.
- Use standard acne care options they recommend (topical treatments are often used first).
- Seek prompt medical advice if you also develop severe rash, skin pain, blistering, or signs of infection rather than typical acne. [1]
When is it more serious than typical acne?
Contact your clinician urgently if the skin changes do not look like ordinary acne (for example, blistering, widespread rash, or symptoms that suggest infection). Serious skin reactions are uncommon, but any rapidly worsening or atypical skin involvement should be evaluated. [1]
Does acne mean Rinvoq is being stopped?
Not necessarily. Many patients can continue Rinvoq while treating acne, but the decision depends on severity and other factors (overall side effects, response to treatment, and your medical history). Your prescriber will decide whether dose adjustment or stopping therapy is needed based on how severe the skin reaction is. [1]
Sources
- https://www.drugs.com/sfx/rinvoq-side-effects.html