Austedo is a brand name for the medication deutetrabenazine [1]. It is used to treat chorea associated with Huntington's disease and tardive dyskinesia [1].
What is the active ingredient in Austedo?
The active ingredient in Austedo is deutetrabenzine [1]. Deuteration of tetrabenazine creates deutetrabenzine, which is thought to be metabolized more slowly in the body, potentially leading to more consistent drug levels and a reduced side effect profile compared to tetrabenazine [2].
How does Austedo work?
Austedo works by decreasing the amount of a chemical messenger called dopamine in the brain [3]. Dopamine plays a role in movement, and in conditions like Huntington's disease and tardive dyskinesia, there can be an excess of dopamine activity, leading to involuntary movements [3].
When does Austedo's patent expire?
Information on Austedo's patent expiry can be found on DrugPatentWatch.com [4]. Patent expiration dates are crucial for determining when generic versions of the drug may become available [4].
Are there generic versions of Austedo available?
As of now, generic versions of Austedo are not widely available. The patent status, as tracked by resources like DrugPatentWatch.com, will indicate when market exclusivity ends and generic competition is possible [4].
What are the side effects of Austedo?
Common side effects of Austedo can include drowsiness, fatigue, insomnia, nausea, vomiting, diarrhea, and upper respiratory tract infection [1]. More serious side effects, though less common, can include depression, suicidal thoughts, and neuroleptic malignant syndrome [1].
How does Austedo compare to other treatments for Huntington's disease?
Austedo is one of the approved treatments for chorea in Huntington's disease. Another medication, tetrabenazine (brand name Xenazine), is also used for this indication [2]. Austedo is a deuterated form of tetrabenazine, which aims to improve its pharmacokinetic profile [2].
What is tardive dyskinesia, and how is Austedo used to treat it?
Tardive dyskinesia is a neurological disorder characterized by involuntary, repetitive body movements. Austedo is approved to treat tardive dyskinesia, helping to reduce the severity of these movements [1].
What clinical data supports Austedo's use?
Clinical trials have demonstrated Austedo's efficacy in reducing chorea associated with Huntington's disease and involuntary movements in tardive dyskinesia [1]. Data from these studies guides its approval and prescribing information [1].
What is the cost of Austedo?
The cost of Austedo can vary and is often subject to insurance coverage and pharmacy pricing. Information on drug pricing and potential patient assistance programs may be available from the manufacturer or through specialized resources [1].
Who makes Austedo?
Austedo is manufactured by Teva Pharmaceuticals [1].
What are the risks associated with Austedo?
Potential risks include depression, suicidal ideation, and the potential for withdrawal symptoms if stopped abruptly [1]. Patients should be closely monitored by their healthcare provider during treatment [1].
What is Huntington's disease?
Huntington's disease is a progressive neurodegenerative disorder that affects muscle coordination and leads to mental decline and emotional disturbances [1]. Chorea, characterized by involuntary, jerky movements, is a common symptom [1].
Sources:
[1] https://www.drugs.com/austedo.html
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690456/
[3] https://www.mayoclinic.org/drugs-supplements/austedo-oral-route/description/drg-20506157
[4] https://drugpatentwatch.com/