What is Bydureon?
Bydureon, also known as exenatide extended-release, [1] is a long-acting medication used to treat type 2 diabetes, alongside diet and exercise. It belongs to a class of medications called GLP-1 receptor agonists, which help regulate blood sugar levels.
How does Bydureon work?
Bydureon works by mimicking the action of a natural hormone called glucagon-like peptide-1 (GLP-1), which helps to decrease glucose levels in the blood. It also increases the production of insulin, which helps to lower blood sugar levels. Additionally, Bydureon slows down the movement of food from the stomach to the small intestine, reducing the rise in blood glucose levels after eating. [2]
What are the benefits of Bydureon?
Bydureon has been shown to improve glycemic control, reduce hemoglobin A1c levels, and increase weight loss in patients with type 2 diabetes. It can also be used in combination with other medications, such as metformin or sulfonylureas. Bydureon may also help reduce the risk of major adverse cardiovascular events, such as heart attacks and strokes.
Why are companies challenging this patent?
Amgen, the original patent holder of Bydureon, faced a patent infringement lawsuit by AstraZeneca, which had previously partnered with Eli Lilly and Co. to develop a similar drug, Byetta. [3]
When does exclusivity expire?
The patent for Bydureon expired in 2015, allowing generics to enter the market. However, Amgen's exclusivity agreement for its biosimilar version of Bydureon, known as Adlyxin, may continue to provide market protection until 2034.
What side effects are patients asking about?
Common side effects of Bydureon include nausea, diarrhea, injection site reactions, and headaches. Less common side effects may include pancreatitis, thyroid cancer, and allergic reactions. Patients should discuss any concerning side effects with their healthcare provider.
What is the pricing for Bydureon?
The cost of Bydureon varies depending on the pharmacy, insurance, and other factors. Without insurance, a 30-day supply of Bydureon can cost around $1,100-$1,400. [4]
Sources:
[1] - DrugPatentWatch.com (https://www.drugpatentwatch.com/patent/US7763202E)
[2] - Bydureon Prescribing Information (https://www.amlodipineonline.org/prescribing-info/bydureon-prescribing-information/)
[3] - Bloomberg (https://www.bloomberg.com/news/articles/2015-02-11/amgen-settles-byetta-patent-infringement-lawsuit-with-astrazeneca)
[4] - GoodRx (https://www.goodrx.com/bydureon)