Can lurbinectedin improve immunotherapy resistance?

Can lurbinectedin help overcome immunotherapy resistance?

Lurbinectedin is a synthetic alkaloid derived from sea squirts that inhibits RNA polymerase II, stopping tumor cells from repairing DNA damage and causing cell death. It is approved for relapsed small cell lung cancer after progression on platinum-based chemotherapy.

What happens if lurbinectedin is added to checkpoint inhibitors?

Early clinical data show that combining lurbinectedin with atezolizumab produces overall response rates of 57% in patients with extensive-stage small cell lung cancer who had previously progressed on platinum-based chemotherapy. These rates liegen bei 57% and are higher than the 35% response rates seen with lurbinectedin alone.