The generic price of Linzess is not yet available as the drug is still under patent protection. Linzess, a medication used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC), is marketed by Ironwood Pharmaceuticals and AbbVie [1].
When is Linzess expected to have a generic version?
The patent for Linzess is set to expire in 2027 [2]. This means that generic manufacturers could potentially launch their versions of the drug after this date, subject to regulatory approvals.
How much does Linzess cost without insurance?
The out-of-pocket cost for Linzess can vary significantly depending on the pharmacy, dosage, and the individual's insurance coverage. Without insurance, a 30-day supply of Linzess can cost several hundred dollars. For example, a 290 mcg dosage of 30 capsules might range from $450 to $550 [3].
Are there any discount programs for Linzess?
Ironwood Pharmaceuticals offers a savings program for eligible patients with commercial insurance, which can help reduce out-of-pocket costs. Further details about these programs can be found on the Linzess website [1].
What are the active ingredients in Linzess?
Linzess contains linaclotide as its active ingredient [4]. Linaclotide is a guanylate cyclase-C (GC-C) agonist that works by increasing fluid secretion in the intestines and speeding up transit time [5].
How does linaclotide work in the body?
Linaclotide acts on the intestinal epithelium. It activates guanylate cyclase-C, which leads to an increase in cyclic guanosine monophosphate (cGMP). This process enhances intestinal fluid secretion and transit, thereby alleviating constipation and abdominal pain associated with IBS-C [5].