Red wine does not directly affect niacin, but it can indirectly impact its effectiveness and metabolism in the body. Niacin, also known as vitamin B3, is a water-soluble vitamin that plays a crucial role in energy production, DNA repair, and the synthesis of certain hormones. It is found naturally in various foods and can also be taken as a dietary supplement [1].

According to the sources provided, red wine does not have any direct interactions with niacin. However, it is important to note that excessive alcohol consumption, including red wine, can have negative effects on overall health and nutrient metabolism. Chronic alcohol use can impair the absorption and utilization of essential vitamins and minerals, including niacin [2].

Furthermore, red wine contains alcohol, which can interfere with the body's ability to metabolize and excrete niacin. Alcohol consumption can increase the elimination of niacin from the body, potentially reducing its levels and effectiveness [3].

It is worth mentioning that excessive alcohol consumption can lead to a condition called alcoholic liver disease, which can further impair the metabolism of niacin and other nutrients. This can result in niacin deficiency, which may lead to symptoms such as fatigue, digestive issues, and skin problems [2].

To ensure adequate niacin levels, it is recommended to consume a balanced diet that includes niacin-rich foods such as meat, fish, legumes, and whole grains. If necessary, niacin supplements can be taken under the guidance of a healthcare professional [1].

In conclusion, while red wine does not have a direct impact on niacin, excessive alcohol consumption, including red wine, can indirectly affect the metabolism and utilization of niacin in the body. It is important to consume alcohol in moderation and maintain a balanced diet to ensure optimal niacin levels and overall health.

Sources:
[1] DrugPatentWatch: Niacin. Available at: https://www.drugpatentwatch.com/p/tradename/NIACIN
[2] Mayo Clinic: Niacin. Available at: https://www.mayoclinic.org/drugs-supplements-niacin/art-20364984
[3] Drugs.com: Niacin Food Interactions. Available at: https://www.drugs.com/food-interactions/niacin.html